Épidémiologie de Pseudomonas aeruginosa chez les patients mucoviscidosiques

We show here a retrospective (2004-2005) and prospective (2006-2010) genotyping study of P. aeruginosa isolates from cystic fibrosis patients in the Armand Trousseau cystic fibrosis center, which illustrates the performance of MLVA. This study allowed to determine the genotype of isolates from every patients from primo-colonisation to chronic infection, as well as isolates found in other patients. Genetic profiles were compared to those of hundreds of isolates from different origins allowing the identification of clones preferentially associated to cystic fibrosis. The routine use of this technology with results that feed databases accessible on the web should allow to considerably modify the way we follow the origin of these bacterial infections and to rapidly intervene in order to control the emergence of new variants.