Immunologie de la transplantation : rejets et infections en transplantation d'organes solides

Graft rejection reactions involved donor allo-antigens, recipients developed deleterious humoral and cellular immune reactions. These reactions will be responsible for tissular damages and had short and long term consequences on organ functions. Inflammatory and cytotoxic reactions against viral infections, particularly CMV infections, are also deleterious for graft tissue and favourable to allogenic immune reactions. Relations between graft rejection and anti-viral reactions are complex and involved immune actors and mechanisms. Viral infections and their specific immune memory also interfere with graft tolerance set up. In this article, graft rejection actors and mechanisms, and their interaction with viral infections will be described.