Core-shell structured magnetic metal-organic framework composites for highly selective enrichment of endogenous N-linked glycopeptides and phosphopeptides

Core-shell structured magnetic metal-organic framework composites denoted as Fe3O4@MIL‐100(Fe) were synthesized and successfully utilized to enrich N-linked glycopeptides and phosphopeptides from trypsin digests of standard proteins and endogenous N-linked glycopeptides and phosphopeptides from human saliva by hydrophilic interaction chromatography (HILIC) and immobilized metal ion affinity chromatography (IMAC).156