Synthesis of a selective ratiometric fluorescent probe based on Naphthalimide and its application in human cytochrome P450 1A

A novel ratiometric fluorescent probe based on 1, 8-naphthalimide with large Stokes' shift was developed to sensitively and selectively detect CYP1A enzymes in physiological conditions and real bio-sample (Human liver microsomes), which was applicable in bioimaging.103