Stability-indicating capillary zone electrophoresis method for the assessment of recombinant human interleukin-11 and its correlation with reversed-phase liquid chromatography and biossay

Representative CZE electropherograms showing peak 1=rhIL-11; peak 2=internal standard (IS); peak 3, 4, 5=degraded forms; peak 6=hydrogen peroxide; peak 7=glycine. (a) BRS-rhIL-11; (b) sample of biopharmaceutical formulation. BRS-rhIL-11 following degradation under conditions (c) basic hydrolysis, (d) acid hydrolysis, (e) photolytic, and (f) oxidative.119