A novel matrix additive, MCM-41-type mesoporous silica nanoparticles, used for analysis of peptides by MALDI-FT/ICRMS

► DHB coupled with MSNs could be useful for the detection of molecule below 500 Da. ► Sample preparation was simple. ► With MSNs as a matrix additive, saturated DHB aqueous solution could be used as the need was to confirm only appropriate laser power but not analyte-to-matrix ratio to reduce matrix ions.