NMR analysis of the rat neurochemical changes induced by middle cerebral artery occlusion

► Ischemic stroke causes both morbidity and mortality affecting the health of millions of people worldwide every year. ► Middle cerebral artery occlusion (MCAO) causes significant systematic cerebral metabolic changes reflecting extensive perturbations in tricarboxylic acid cycle, GABA shunt, and metabolisms of choline and nucleic acids. ► Metabonomic analysis is a useful tool for understanding the neurochemistry of stroke and other neurodegenerative disorders.