Analytical control strategies for mutagenic impurities: Current challenges and future opportunities?

This review examines the impact of these changes on the approaches taken to the analysis of MIs. Observed is the emergence of platform approaches; methods that can be applied to a class of MIs rather than simply to individual analytes. Another observation and concern is the continued development of highly specific sensitive methods for analytes, where appropriate knowledge of the status of the analyte (i.e. it is actually non-mutagenic), would have precluded the necessity to do so. This illustrates the need to conduct a thorough review of the available literature before analytical method development is commenced.