High-precision isotopic analysis of essential mineral elements in biomedicine: natural isotope ratio variations as potential diagnostic and/or prognostic markers

- High-precision isotopic analysis of Ca, Cu, Fe and Zn reveals clinically relevant information.
- Isotope ratio variability among organs, biofluids, tissues and bone.
- As a first stage, factors affecting isotope ratios were studied in controls.
- Isotope ratio data show diagnostic and prognostic capabilities.