کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7747818 | 1498674 | 2018 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Near-infrared fluorescent probes for peptidases
ترجمه فارسی عنوان
پروب های فلورسنت نزدیک به مادون قرمز برای پپتیدی ها
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
چکیده انگلیسی
Near-infrared (NIR) fluorescent probes possess a characteristic molecular structure with a highly conjugated polyene or polynuclear system, thus exhibiting a long emission wavelength over 650Â nm up to 900Â nm. They are of increasing interest owing to their capability of deep tissue penetration as well as low spectral interference with biomolecules in the living system. In this review, we will examine typical molecular structures of NIR fluorophores and then describe their enzymatic reactions with peptidases from the viewpoint of chemical design and reaction mechanism. The targeting enzymes will be covered from aminopeptidase, glutamyltranspeptidase, protease to penicillin G-amidase. Further application to tumor imaging and therapy is also discussed as a theranostic approach.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Coordination Chemistry Reviews - Volume 354, 1 January 2018, Pages 169-181
Journal: Coordination Chemistry Reviews - Volume 354, 1 January 2018, Pages 169-181
نویسندگان
Jik Chin, Hae-Jo Kim,