Folding of dinuclear platinum anticancer complexes within the cavity of para-sulphonatocalix[4]arene

► The dinuclear complexes fold to maximise contact with the cavity of the macrocycle. ► Encapsulation of the complexes within the macrocycle is driven by hydrophobic and ion-dipole forces. ► The macrocycle has differing affects on the metal complexes' cytotoxicity depending on the cell line.