Synthesis and characterisation of metallopolyamide complexes

► Two Pt(II) and Ru(II) polyamides were synthesised using solution and solid phase chemistry. ► Characterisation was achieved using NMR, UV-Vis and ESI-MS and CD for Δ- and Λ-RUP1. ► Cytotoxicity for Δ- and Λ-RUP1 was greater than 40 μM (48 h). ► LD indicated that the RUP1 interact with DNA but this is influenced by concentration and chirality.