Development of a novel carboplatin like cytoplasmic trackable near infrared fluorophore conjugate via strain-promoted azide alkyne cycloaddition

Reaction of cis-[Pt(2-azidopropane-1,3-diamine)(cbdca)] where cbdca is cyclobutane-1,1-dicarboxylato and a bicyclo[6.1.0]non-4-yne near-infrared fluorophore gave the corresponding strain-promoted azide alkyne clicked Pt-fluorophore conjugate. The in vitro cytotoxicity and widefield fluorescence imaging of the carboplatin-like fluorophore conjugate in A2780P and A2780cisR cells are described.152