Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study

Nonfunctionalized SBA-15 (Santa Barbara Amorphous 15) mesoporous silica and functionalized with 3-mercaptopropyltriethoxysilane, SBA-15~SH, were used as carriers for [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}], [Ru]. Materials containing [Ru] showed high activity against B16 and B16-F10 cell lines, 3-6 times higher than [Ru]. Apoptosis with suppressed autophagy was detected in B16 cells.108