N7-platinated ribonucleotides are not incorporated by RNA polymerases. New perspectives for a rational design of platinum antitumor drugs

Possible incorporation into RNA of the NTPs platinated model [Pt(dien)(N7-5′-GTP)] (dien = diethylenetriamine; GTP = 5′-guanosine triphosphate) has been studied. The inability of the model T7 RNA polymerase to use platinated nucleotides as substrates has been assessed. Our results suggest new pharmacological strategies to specifically target DNA, without affecting RNA.79