Behavior of the potential antitumor VIVO complexes formed by flavonoid ligands. 2. Characterization of sulfonate derivatives of quercetin and morin, interaction with the bioligands of the plasma and preliminary biotransformation studies

The biotransformation in the plasma and red blood cells of VIVO2 + complexes formed by flavonoid ligands with potential antitumor activity was studied at the physiological pH. The formation of secondary bonds between the bis-chelated VIVO species and the proteins was also demonstrated.151