Occupying a flat subpocket in a tRNA-modifying enzyme with ordered or disordered side chains: Favorable or unfavorable for binding?

Occupying a flat subpocket in a tRNA-modifying enzyme with ordered or disordered side chains: Favorable or unfavorable for binding?

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 24, Issue 20, 15 October 2016, Pages 4900-4910

Manuel Neeb, Christoph Hohn, Frederik Rainer Ehrmann, Adrian Härtsch, Andreas Heine, François Diederich, Gerhard Klebe,