کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7780962 | 1500558 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel pH-responsive hydrogel based on carboxymethyl cellulose/2-hydroxyethyl acrylate for transdermal delivery of naringenin
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کلمات کلیدی
2-hydroxyethyl acrylateCMCTGApH-responsive hydrogelKPSNRGPBSTDDsThermogravimetric analysis - تجزیه و تحلیل ترموگرافیTransdermal delivery system - سیستم تحویل transdermalTransdermal drug delivery system - سیستم تحویل داروی ترانس خرابکارانهphosphate buffer solution - محلول بافر فسفاتNaringenin - نایرینگینینPotassium persulfate - پراسفیلات پتاسیمPoly(ethylene glycol) diacrylate - پلی اتیلن گلیکول دی اکریلاتPEGDA - پگداCarboxymethyl cellulose - کربوکسی متیل سلولز
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study, a pH-responsive hydrogel (cl-CMC-g-pHEA), based on carboxymethyl cellulose/2-hydroxyethyl acrylate, was prepared. Its physicochemical properties and applicability as a transdermal delivery system for naringenin (NRG) were investigated. The hydrogel was synthesized via radical polymerization; its structure was analyzed by FT-IR and 1H NMR. The water loss amount was measured by using thermogravimetric analysis; a porous 3D network structure was confirmed by SEM. All hydrogels showed greater swelling ratio at pH 7.5 and 8.5 than at pH 5.5. Rheological and texture analyses indicated a stable gel network and that grafting and crosslinking density influenced the mechanical properties of the hydrogel. The release behavior of NRG from the hydrogel could be explained by the Fickian diffusion mechanism. The hydrogel system enhanced transdermal delivery of NRG. Therefore, this novel pH-responsive cl-CMC-g-pHEA hydrogel may be useful as a transdermal delivery system for NRG and has potential applications in the treatment of atopic dermatitis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 200, 15 November 2018, Pages 341-352
Journal: Carbohydrate Polymers - Volume 200, 15 November 2018, Pages 341-352
نویسندگان
So Hyun Park, Hyuk Soo Shin, Soo Nam Park,