کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7782687 | 1500566 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization and microbiological evaluation of chitosan-alginate microspheres for cefixime vaginal administration
ترجمه فارسی عنوان
ارزیابی و ارزیابی میکروبیولوژیکی میکروسپورهای کیتوزان-آلژینات برای تزریق سفلیسیم واژینال
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Chitosan-alginate microspheres (MS) were developed for cefixime vaginal administration, to overcome problems associated with its oral administration. The effect of increasing drug-loading amount, by keeping the chitosan-alginate content constant, was investigated. Mucoadhesion studies indicated that all formulations assured in situ permanence longer than 2â¯h. Entrapment efficiency increased with drug loading concentration in the starting solution, reaching a plateau at 30â¯mg/mL indicative of the achievement of an optimal drug-to-polymer ratio. MS swelling properties increased with the entrapped drug amount, and, interestingly, water-uptake reached its maximum value at the same drug loading concentration of 30â¯mg/mL. The relationship found between MS water-uptake and drug release rate confirmed MS prepared with 30â¯mg/mL cefixime as the best formulation. Microbiological studies showed a relation between cefixime release rate from MS and Escherichia coli viability reduction, definitely indicating the selected MS formulation as the best for an effective local treatment of urogenital infections.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 192, 15 July 2018, Pages 176-183
Journal: Carbohydrate Polymers - Volume 192, 15 July 2018, Pages 176-183
نویسندگان
F. Maestrelli, M. Jug, M. Cirri, I. Kosalec, P. Mura,