کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7783551 | 1500572 | 2018 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Application of response surface methodology to tailor the surface chemistry of electrospun chitosan-poly(ethylene oxide) fibers
ترجمه فارسی عنوان
استفاده از روش سطح پاسخ برای شبیه سازی شیمیایی سطحی الیاف کیتوزان پلی (اتیلن اکسید) الکترو اسپور
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Chitosan is a promising biocompatible polymer for regenerative engineering applications, but its processing remains challenging due to limited solubility and rigid crystalline structure. This work represents the development of electrospun chitosan/poly(ethylene oxide) blend nanofibrous membranes by means of a numerical analysis in order to identify and tailor the main influencing parameters with respect to accessible surface nitrogen functionalities which are of importance for the biological activity as well as for further functionalization. Depending on the solution composition, both gradient fibers and homogenous blended fiber structures could be obtained with surface nitrogen concentrations varying between 0 and 6.4%. Response surface methodology (RSM) revealed chitosan/poly(ethylene oxide) ratio and chitosan molecular weight as the main influencing factors with respect to accessible nitrogen surface atoms and respective concentrations. The model showed good adequacy hence providing a tool to tailor the surface properties of chitosan/poly(ethylene oxide) blends by addressing the amount of accessible chitosan.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 186, 15 April 2018, Pages 122-131
Journal: Carbohydrate Polymers - Volume 186, 15 April 2018, Pages 122-131
نویسندگان
Peter Bösiger, Isabelle M.T. Richard, Luce Le Gat, Benjamin Michen, Mark Schubert, René M. Rossi, Giuseppino Fortunato,