کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7787220 | 1500624 | 2015 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation of alginate-chitosan fibers with potential biomedical applications
ترجمه فارسی عنوان
آماده سازی فیبرهای آلژینات-کیتوزان با کاربرد بالینی زیست پزشکی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
The preparation of alginate-chitosan fibers, through wet spinning technique, as well as the study of their properties as a function of chitosan's molecular weight and retention time in the coagulation bath, is presented and discussed in this work. Scanning electron microscopy (SEM) revealed that the fibers presented irregular and rough surfaces, with a grooved and heavily striated morphology distributed throughout the structure. Dynamic mechanical analysis (DMA) showed that, with the exception of elongation at break, the incorporation of chitosan into the fibers improved their tensile properties. The in vitro release profile of sulfathiazole as a function of chitosan's molecular weight indicated that the fibers are viable carriers of drugs. Kinetic models showed that the release of the model drug is first-order, and the release mechanism is governed by the Korsmeyer-Peppas model. Likewise, fibers loaded with sulfathiazole showed excellent inhibition of Escherichia coli growth after an incubation time of 24 h at 37 °C.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 134, 10 December 2015, Pages 598-608
Journal: Carbohydrate Polymers - Volume 134, 10 December 2015, Pages 598-608
نویسندگان
Bernal Sibaja, Edward Culbertson, Patrick Marshall, Ramiz Boy, Roy M. Broughton, Alejandro Aguilar Solano, Marianelly Esquivel, Jennifer Parker, Leonardo De La Fuente, Maria L. Auad,