کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7788049 | 1500629 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization and evaluation of synthetic riluzole with β-cyclodextrin and 2,6-di-O-methyl-β-cyclodextrin inclusion complexes
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کلمات کلیدی
β-Cyclodextrinriluzole (PubChem CID: 5070)β-cyclodextrin (PubChem CID: 444041) - β-سیکلوکودکسترون (PubChem CID: 444041)Ethanol (PubChem CID: 702) - اتانول (PubChem CID: 702)Solubilization - حلال سازیDimethyl sulfoxide (PubChem CID: 679) - دی متیل سولفوکسید (PubChem CID: 679)riluzole - ریلوزولHepatotoxicity - سمیت کبدMethanol (PubChem CID: 887) - متانول (PubChem CID: 887)Inclusion complex - مجتمع گنجاندن
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Characterization and evaluation of synthetic riluzole with β-cyclodextrin and 2,6-di-O-methyl-β-cyclodextrin inclusion complexes Characterization and evaluation of synthetic riluzole with β-cyclodextrin and 2,6-di-O-methyl-β-cyclodextrin inclusion complexes](/preview/png/7788049.png)
چکیده انگلیسی
β-Cyclodextrin (β-CD) and 2,6-di-O-methyl-β-cyclodextrin (DM-β-CD) inclusion complexes with riluzole (RLZ) were prepared to improve water solubility and broaden potential pharmaceutical applications. CDs/RLZ inclusion complexes were confirmed via phase solubility studies, FT-IR spectroscopy, PXRD, DSC, 1H NMR, and SEM. Phase solubility studies indicated that β-CD and DM-β-CD can form 1:1 inclusion complexes with RLZ, and the stability constants were 663.17 and 1609.07 Mâ1, respectively. Water solubility and dissolution rate of RLZ were significantly improved in complex forms, implying that the inclusion complexes may develop pharmaceutical applications. Preliminary in vitro cytotoxicity assay also showed that RLZ hepatotoxicity was not increased in the inclusion complexes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 129, 20 September 2015, Pages 9-16
Journal: Carbohydrate Polymers - Volume 129, 20 September 2015, Pages 9-16
نویسندگان
Lili Wang, Shanshan Li, Peixiao Tang, Jin Yan, Kailin Xu, Hui Li,