کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7790613 | 1500643 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
NMR investigation of the complexation and chiral discrimination of pyrazole sulfonamide derivatives with cyclodextrins
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: NMR investigation of the complexation and chiral discrimination of pyrazole sulfonamide derivatives with cyclodextrins NMR investigation of the complexation and chiral discrimination of pyrazole sulfonamide derivatives with cyclodextrins](/preview/png/7790613.png)
چکیده انگلیسی
The complexes formed between six original chiral diaryl-pyrazole sulfonamide derivatives, displaying poor solubility, and various CDs (native α-, β- and γ-CDs, hydroxypropylated HP-β-CD, methylated Me-β-CD or amino NH2-β-CD) were studied by 1D and 2D 1H NMR at physiological pH in order to determine their apparent binding constant, stoichiometry and structure of the supramolecular assembly. For some complexes, the spectra obtained for free racemic compound and for racemic compound in presence of CD indicate a splitting of signal(s). Additional experiments with pure enantiomer and enriched enantiomer allow us to attribute this behavior to chiral discrimination. The complexing ability of the native β-CD towards our compounds appears the most promising since binding values around 7 Ã 102 Mâ1 are obtained. The two-dimensional ROESY (1H-1H) experiments prove the inclusion of the aliphatic part of the compound in the CD cavity. It is noteworthy that this inclusion occurs via the smaller opening of the cavity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 115, 22 January 2015, Pages 598-604
Journal: Carbohydrate Polymers - Volume 115, 22 January 2015, Pages 598-604
نویسندگان
Tiphaine Rogez-Florent, Nathalie Azaroual, Laurence Goossens, Jean-François Goossens, Cécile Danel,