کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7791870 | 1500647 | 2014 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anti-tumor properties of orally administered glucosamine and N-acetyl-d-glucosamine oligomers in a mouse model
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The current study evaluated the anti-tumor activities of N-acetyl-d-glucosamine oligomer (NACOS) and glucosamine oligomer (COS) after their oral administration in a tumor (colon 26)-bearing mouse model. Compared to the control group, NACOS and COS groups showed significantly suppressed tumor growth, and apparent, marked apoptosis in tumor tissues. Furthermore, serum interleukin-12p70 and interferon-γ levels significantly increased in the NACOS and COS groups compared to the corresponding levels in the control group. Collectively, the results indicate the oral administration of NACOS and COS could enhance innate immunity. Results of experiments in Myd-88 knockout mice revealed that the apparent effects were related to both Myd-88-dependent and Myd-88-independent pathways. The data indicated that oral administration of NACOS and COS produced anti-tumor effects through the induction of apoptosis and stimulation of the immune system, which suggests that NACOS and COS are candidate anti-tumor functional foods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 111, 13 October 2014, Pages 783-787
Journal: Carbohydrate Polymers - Volume 111, 13 October 2014, Pages 783-787
نویسندگان
Sachie Masuda, Kazuo Azuma, Seiji Kurozumi, Masatoshi Kiyose, Tomohiro Osaki, Takeshi Tsuka, Norihiko Itoh, Tomohiro Imagawa, Saburo Minami, Kimihiko Sato, Yoshiharu Okamoto,