In vitro investigations of α-amylase mediated hydrolysis of cyclodextrins in the presence of ibuprofen, flurbiprofen, or benzo[a]pyrene

► Porcine pancreatic α-amylase degrades γ- and hydroxypropyl-γ-cyclodextrins. ► α-, β- and hydroxypropyl-β-cyclodextrins are only degraded to a very limited extent. ► Degradation of hydroxylpropyl-γ-cyclodextrin depends on the degree of substitution. ► Complexation affects the degradation of the cyclodextrins in a limited way. ► γ-Cyclodextrins and derivatives seem as suitable vehicles for early animal experiments.