Tuning the molecular/electronic structure of new substituted pyrazoles: Synthesis, biological trials, theoretical approaches and Hammett correlations

Synthesis, characterization and biological trials of pyrazoles with general name (E)-3,5-dimethyl-1-(4-R-phenyl)-4-(phenyldiazenyl)-1H-pyrazoles (with R = 4-CH3O (1), 4-CH3 (2), 4-H (3), 4-F (4), 4-Cl (5), 4-CF3 (6), 4-CN (7), 4-NO2 (8), 3-Cl (9), 3-NO2 (10), 2-Cl (11) and C6F5 (12)). The structures of 4, 5 and 8 were reached by X-Ray diffraction. Also, molecular/electronic structure was tuned by means of changing the R substituent. Biological activity, specifically anticancer were observed against cancer cell lines (60), including leukemia, colon and brain cancer.533