کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7810077 1501763 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tautomeric and ionisation forms of dopamine and tyramine in the solid state
ترجمه فارسی عنوان
اشکال تتوومر و یونیزاسیون دوپامین و تیامین در حالت جامد
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
Crystallisation of the phenylethylamine neurotransmitter dopamine from basic aqueous solution yielded the 3-phenoxide Zwitterionic tautomer, despite this being a minority form in the solution state. In the crystal structure, dopamine has a dimeric [OCCOH]2 hydrogen bonded catechol motif that expands through NH⋯O interactions to give a 2-dimensional sheet of classical hydrogen bonds. These sheets are further interconnected by NH⋯π interactions. The structurally related base tyramine crystallises under similar conditions as a hemihydrate with all four possible species of tyramine present (cationic, anionic, Zwitterionic and neutral) in the crystal structure. Single crystal X-ray diffraction studies at 121 and 293 K showed dynamic hydrogen atom disorder for the phenol/phenoxide group, suggesting that the tyramine speciation observed arises from a solid-state process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 1051, 5 November 2013, Pages 132-136
نویسندگان
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