کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7810793 1501766 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, chemical characterization, DNA binding and antioxidant studies of ferrocene incorporated selenoure
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, chemical characterization, DNA binding and antioxidant studies of ferrocene incorporated selenoure
چکیده انگلیسی
In this article we have reported synthesis, chemical characterization (with single crystal XRD, elemental analysis, FTIR and multinuclear NMR spectroscopy), DNA binding (with cyclic voltammetry, UV-vis spectroscopy, molecular docking and viscometry) and antioxidant activities (1,1-diphenyl-2-picrylhydrazyl scavenging) of 1-(2-methylbenzoyl)-3-(3-ferrocenylphenyl)selenourea (MOT). We found that this compound interacts electrostatically with DNA and has a binding constant value of 1.703 × 104 M−1. Lower value of diffusion coefficient for MOT-DNA adduct (1.35 × 106 cm2 s−1) relative to free MOT (1.66 × 106 cm2 s−1) in cyclic voltammetry (CV) indicated the binding of the compound with DNA. Smaller value of binding site size (0.88 base pairs) in CV, hyperchromism in UV-vis spectroscopy and decrease of relative specific viscosity of DNA in viscometry favored electrostatic interactions. Binding energy of experimental (−5.77 kcal mol−1) and simulated (−5.86 kcal mol−1) work are in close agreement with each other. IC50 value of MOT for 1,1-diphenyl-2-picrylhydrazyl scavenging was found to be 27 μM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 1048, 24 September 2013, Pages 367-374
نویسندگان
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