DOX/IL-2/IFN-γ co-loaded thermo-sensitive polypeptide hydrogel for efficient melanoma treatment

Schematic illustration for the mechanism of DOX/IL-2/IFN-γ co-loaded hydrogel of PELG7-PEG45-PELG7 on melanoma local treatment in nude mice: the released drugs from the hydrogel could induce the cell apoptosis as well as promote the proliferation of CD3+/CD4+ T-lymphocytes and CD3+/CD8+ T-lymphocytes to cause enhanced anti-tumor efficacy against melanoma xenograft in mice model.351