Dual-stimuli-responsive albumin-polyplex nanoassembly for spatially controlled gene release in metastatic breast cancer

Dual stimuli responsive nanoassembly was developed by forming complex between the bovine serum albumin loaded IR780 dye with DNA polyplex, which improved the transfection efficiency by photothermally endosomal escape as well as gluthione redox mediated DNA release from polyplex. Additionally, it possess the ability to penetrate the tumor spheroid.256