Multifunctional nanoparticles for cancer immunotherapy: A groundbreaking approach for reprogramming malfunctioned tumor environment

(A) Photoactivatable nanomicelles complex with PDL-1 siRNA for combination of cancer immunotherapy and photodynamic therapy. (B) Molecular mechanism of tumor immune cell inhibition and activation of T-cell. (C) PET/CT scan of patient indicates the superior tumor growth inhibition after 8 months treatment of immunotherapy. Image (A) [99], B [100], (C) [101] are adopted and reproduced with permissions.289