کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7861561 | 1509014 | 2016 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of disulfide-bridge on the activities of H-shape gemini-like cationic lipid based siRNA delivery
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The GLCL/siRNA nanoplexes were prepared with electrostatic interaction. After cell internalization, the ssGLCLs were split into two single chain lipid units with the cleavage of disulfide-bridge by abundant reductive glutathione (GSH) in cells, then the resulted monomeric lipid unit exhibited higher membrane fusion and facilitated release of siRNA from lysosomes into cytoplasm, thus the enhanced gene silencing effects on targeted mRNA were obtained.208
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 235, 10 August 2016, Pages 99-111
Journal: Journal of Controlled Release - Volume 235, 10 August 2016, Pages 99-111
نویسندگان
Xiao-Fei Ma, Jing Sun, Chong Qiu, Yi-Fan Wu, Yi Zheng, Min-Zhi Yu, Xi-Wei Pei, Lin Wei, Yu-Jie Niu, Wen-Hao Pang, Zhen-Jun Yang, Jian-Cheng Wang, Qiang Zhang,