Global dynamics of an age-structured cholera model with both human-to-human and environment-to-human transmissions and saturation incidence

In this paper, an age-structured cholera model with both human-to-human and environment-to-human transmissions and saturation incidence is proposed. In the model, we consider the infection age of infectious individuals and the biological age of pathogen in the environment. It is verified that the global dynamics of the model is completely determined by the basic reproduction number. Asymptotic smoothness is verified as a necessary argument. By analyzing corresponding characteristic equations, we discuss the local stability of each of feasible steady states. Uniform persistence is shown by using the persistence theory for infinite dimensional dynamical system. The global stability of each of feasible steady states is established by using suitable Lyapunov functionals and LaSalle's invariance principle. Numerical simulations are carried out to illustrate the theoretical results.