کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8258592 1534611 2018 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of central neurotensin in regulating feeding: Implications for the development and treatment of body weight disorders
ترجمه فارسی عنوان
نقش نورونتنسین مرکزی در تنظیم تغذیه: پیامدهای توسعه و درمان اختلالات وزن بدن
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
The peptide neurotensin (Nts) was discovered within the brain over 40 years ago and is implicated in regulating analgesia, body temperature, blood pressure, locomotor activity and feeding. Recent evidence suggests, however, that these disparate processes may be controlled via specific populations of Nts neurons and receptors. The neuronal mediators of Nts anorectic action are now beginning to be understood, and, as such, modulating specific Nts pathways might be useful in treating feeding and body weight disorders. This review considers mechanisms through which Nts normally regulates feeding and how disruptions in Nts signaling might contribute to the disordered feeding and body weight of schizophrenia, Parkinson's disease, anorexia nervosa, and obesity. Defining how Nts specifically mediates feeding vs. other aspects of physiology will inform the design of therapeutics that modify body weight without disrupting other important Nts-mediated physiology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1864, Issue 3, March 2018, Pages 900-916
نویسندگان
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