Regenerative activity of the lung after epithelial injury

► Introduction of the epithelial-mesenchymal transition (EMT) concept derived from developmental and cancer biology ► EMT and associated signaling pathways in lung repair and fibrosis ► EMT phenotypes and their relationship to a pluripotent state or “stemness” ► Candidate airway and alveolar progenitor cells responsible for lung regeneration ► Newly appreciated injury models demonstrating regeneration of functional pulmonary structures