Impact of obesity on IL-12 family gene expression in insulin responsive tissues

► IL-12 cytokines and receptors are regulated in insulin-responsive tissues by obesity. ► IL-12 family genes divergently regulated with obesity in a tissue-specific manner. ► IL-12 genes regulated in adipose tissue by developmental stage of obesity. ► IL-12 genes regulated in adipose tissue by inflammatory stress of obesity. ► IL-12 cytokines and receptors are regulated in adipocytes by inflammatory stress.