Mutant huntingtin regulates EGF receptor fate in non-neuronal cells lacking wild-type protein

► Polyglutamine (polyQ) expansion in huntingtin (htt) protein causes Huntington's disease (HD). ► PolyQ-htt-induced alteration of EGFR trafficking affects cell migration and proliferation by EGF. ► Alteration in EGFR trafficking occcurs, at least in part, through inhibition of ERK signaling.