Transport and distribution of 45Ca2Â + in the perfused rat liver and the influence of adjuvant-induced arthritis

► Ca2 + transport in the liver was examined by multiple-indicator dilution technique. ► A four-pool model for Ca2 + distribution was devised for steady state conditions. ► Arthritis alters Ca2 + exchange in the hormone-sensitive cellular pool. ► Modifications in Ca2 + homeostasis caused by diseases can be kinetically evaluated.