Impaired protein quality control system underlies mitochondrial dysfunction in skeletal muscle of streptozotocin-induced diabetic rats

► After 4 months of STZ administration gastrocnemius IMF mitochondria functionality decreased. ► Increased mitochondria carbonylation levels were paralleled by decreased OXPHOS activity. ► Decreased mitochondria proteolysis was related with increased protein oxidation. ► AAA proteases activity and expression decreased in diabetic animals.