Age-related impairments in memory and in CREB and pCREB expression in hippocampus and amygdala following inhibitory avoidance training

► Old rats exhibit memory impairments following inhibitory avoidance training. ► Memory impairments are evident following a low but not moderate foot shock. ► Old rats have deficits in total CREB and in pCREB activation following training. ► pCREB deficits in old rats are present regardless of foot shock intensity.