Age-related changes in gene expression in tissues of the sea urchin Strongylocentrotus purpuratus

► Sea urchins are novel model animals for studying aging and negligible senescence. ► Muscle, esophagus and nerve tissue show age-related changes in gene expression. ► With age there is increased expression of genes involved in protein homeostasis. ► With age there is increased expression of components of Notch signaling pathway. ► With age there is decreased expression of components of Wnt signaling pathway.