Lamin A/C deficiency is associated with fat infiltration of muscle and bone

► Osteopenia and sarcopenia are age-related entities that may have common mechanisms. ► Lamin A/C has been associated with the regulation of stem cell differentiation. ► Mice lacking lamin A/C show fat infiltration in muscle and bone. ► Both muscle and bone of lamin A/C knockout mice show a predominant expression of adipogenic factors. ► Lamin A/C is a potential factor involved in the pathogenesis of sarco and osteopenia in ageing.