Transcriptional changes of secreted Wnt antagonists in hindlimb skeletal muscle during the lifetime of the C57BL/6J mouse

► Large numbers of secreted Wnt antagonists are repressed in adult and old muscles. ► The repression of Wnt antagonists is possibly related to altered chromatin states. ► Changes of chromatin modifications are similar among the studied antagonists. ► FOXD3 might be an upstream factor mediating the observed transcriptional changes.