Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway

► Direct measurements suggest that ROS levels do not negatively affect lifespan. ► misc-1 mutants have high ROS levels but wild-type lifespan. ► gei-7 transcriptional levels are suggestive of longevity in mitochondrial mutants. ► gei-7 suppresses the longevity of clk-1 mutants.