کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8292555 1536734 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel phosphorelay-dependent control of ZFP36L1 protein during the cell cycle
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Novel phosphorelay-dependent control of ZFP36L1 protein during the cell cycle
چکیده انگلیسی
The ZFP36 family is a prototypical member of a highly conserved group of proteins with CCCH-type RNA-binding domains, whose functional role and regulatory mechanism in mitotic cells remain obscure. In this study, we provide the first evidence that ZFP36L1 phosphorylation is modulated in a cell cycle-dependent manner. The C-terminal region of ZFP36L1 is critical for its cell cycle-dependent phosphorylation of this protein. We also suggest that the phosphorelay-dependent regulation of ZFP36L1 influences mitotic spindle organization. Thus, our data demonstrate a new class of regulatory mechanism for CCCH-type zinc-finger proteins in cell cycle control.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 501, Issue 2, 22 June 2018, Pages 387-393
نویسندگان
, , , , , ,