کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8292870 1536738 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V
چکیده انگلیسی
In this study, we focused on a lysosomal protease cathepsin V (CTSV) to clarify the mechanism underlying melanosome degradation in the keratinocytes. Using immunohistochemical observation, we found that CTSV was highly expressed across the entire epidermis in normal skin; however, CTSV expression levels were lower in the basal layer than those in the stratum corneum side in the hyperpigmented region. Moreover, we found that melanosome degradation was suppressed in CTSV knockdown cells. These results indicated that CTSV is involved in melanosome degradation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 500, Issue 2, 2 June 2018, Pages 339-343
نویسندگان
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