کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8292924 | 1536738 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Epitope-based ligation of ICAM-1: Therapeutic target for protection against the development of rheumatoid arthritis
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کلمات کلیدی
DIPTNFELISPOTDMARDmetacarpophalangealinterphalangealMCPPBMCmAbcollagen-induced arthritis - آرتروز ناشی از کلاژنRheumatoid arthritis - آرتریتروماتوئیدMonoclonal antibody - آنتی بادی مونوکلونالAntigen-specific - آنتیژن اختصاصیinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینProximal interphalangeal - بین فلامنگار پروگزیمالdisease-modifying anti-rheumatic drug - داروهای ضد روماتیسمی اصلاح کننده بیماریdistal interphalangeal - دیافراگم بین فالانگالPeripheral blood mononuclear cell - سلول تک هسته ای خون محیطیDendritic cell - سلول دندریتیکCIA - سیاcytomegalovirus - سیتومگالوویروسCMV - سیتومگالوویروسtumor necrosis factor - فاکتور نکروز تومورenzyme-linked immunosorbent spot - نقطه آنزیم جذب آنزیمC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی PiP - پیپ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Identification of a particular epitope on the domain 2 of human ICAM-1 led us to focus on its role in the treatment of rheumatoid arthritis (RA). Key observations from our previous xenotransplantation research included the generation of tolerogenic DCs, antigen-specific T-cell tolerance, and reduced production of inflammatory cytokines. The critically important point is the fact that it works initially on DC maturation. Ligation of this epitope with a recognizing antibody, MD-3, was also able to create a tolerogenic environment in RA in a manner sililar to that created by xenotransplantation. In this study, we noted that the disease progression, in terms of arthritis score and histopathology of joints, was significantly less severe in the MD-3-treated group than in the vehicle-treated group. Defective production of IL-6 and reduced proliferation of collagen-specific T cells were most remarkable laboratory findings. This type of ligation has a greater advantage over other types of therapeutics, in a sense that simple injection of this antibody inhibits antigen-specific T cell response. Due to the possibility of viral infection in this process, we regularly monitored cytomegalovirus reactivation status without detection of any viral gene replication. We are hoping that remarkable specializations that this interaction has, would be a promising target for therapeutic antibody in RA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 500, Issue 2, 2 June 2018, Pages 450-455
Journal: Biochemical and Biophysical Research Communications - Volume 500, Issue 2, 2 June 2018, Pages 450-455
نویسندگان
Jae-Il Lee, Hi-Jung Park, Hye-Jin Park, Yun-Jung Choi, Jiyeon Kim, Jin Kyun Park, Kyeong Cheon Jung, Eung-Soo Hwang, Eun Bong Lee, Seong Hoe Park,