Urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine values determined by a modified ELISA improves agreement with HPLC-MS/MS

Correlation between urinary 8-oxodG levels measured by the alCA ELISA kit versus HPLC-MS/MS. A: 8-oxodG levels were measured by ELISA in samples without any pre-treatment, results expressed in ng/mL urine; B: 8-oxodG levels were measured by ELISA in SPE-purified samples; results expressed in ng/mL urine; C: 8-oxodG levels were measured by ELISA in SPE-purified samples; results normalized per creatinine urine. SPE, solid phase extraction; HPLC-MS/MS, high-performance liquid chromatography with tandem mass spectrometry.