Specific stress-induced storage of trehalose, glycerol and d-arabitol in response to oxidative and osmotic stress in Candida albicans

► Candida albicans has evolved a complex defensive response against stress. ► The synthesis of trehalose, glycerol and d-arabitol occurs in a stress-specific dependent manner. ► Trehalose and d-arabitol are accumulated in response to oxidative stress. ► Osmotic challenges induced the storage of glycerol. ► Whereas glycerol synthesis depends on a functional Hog1 pathway, trehalose is Hog1 independent.