Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin

► We investigated pro-survival signaling elicited by subtilase cytotoxin (SubAB). ► SubAB activates ERK and Akt via the PERK-eIF2α pathway. ► This pathway contributes to attenuation of apoptosis triggered by SubAB.